Type II Hypersensitivity

∞ generated and posted on 2016.03.20 ∞

Complement-mediated cellular cytotoxicity of antibody-tagged self cells.

These cytotoxic hypersensitivities give rise to the blood transfusion incompatabilities associated with the ABO blood group system. Type II hypersensitivities also can give rise to erythroblastosis faetalis, which is associated with Rh factor incompatabilities between mother and fetus.

It is also possible for drugs, acting as haptens, to give rise to type II hypersensitivity reactions, such as thrombocytopenic purpura, which results in destruction of the formed elements called platelets.

Type II hypersensitivities are mediate by IgG and IgM immunoglobulins and represent one of the hypersensitivities that can be avoided, in terms of autoimmune disease, as a consequence of clonal deletion.