∞ generated and posted on 2022.02.08 ∞
Bacterial concentration required to allow sufficient phage population growth to exactly offset especialy bacteria-independent phage virion inactivation.
| If and only if bacterial concentrations exceed the phage Proliferation Threshold can net phage population growth occur within a given environment. |
Bacterial concentrations exceeding the phage proliferation threshould is the absolutely minimum requirement for successful active phage therapy, since by definition for active treatment to occur then a phage population must be able to increase in size in situ.
Simply exceeding the proliferation threshold is not sufficent to actively achieve inundative densities of phages, however, since exceeding inundation thresholds only slightly will not result in very rapid phage population growth.
In addition, exceeding inundation thresholds will also not guarantee that sufficiently high phage titers will be achieved, only that phage titers will increase from some original level to some extent.
Note that phage proliferation thresholds are irrelevant, by definition, for passive treatment to be successful in eradicating targetted bacteria.
Next | Previous phage therapy-related terms: Sur Mesure | Professionally Lytic.
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