Biology as Poetry: Genetics

Bacteriophage Ecology Group

Positive Control (of gene expression)

Transcription factor binding to DNA that results in an increase rates of transcription.

Specifically, in positive control of gene expression the protein that binds to DNA facilitates transcription initiation by attracting RNA polymerase binding.

Note that key is that protein binding increases transcription. What controls whether or not a protein is intrinsically able to bind to DNA, that is, whether the protein is active, is beside the point.

See for example catabolite repression/positive control of energy metabolism. Contrast with negative control of gene expression. Note, also in contrast, the concepts simply of positive control and negative control.

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