∞ generated and posted on 2016.01.12 ∞

Disordered change in the conformation of a molecule, particularly a protein, such that the molecule loses its previous function.

The concept of denaturation can also be applied to nucleic acids where it is the separation of double-stranded forms, i.e., as making up a double helix, to single-stranded forms that is described as denaturation. The most common means of denaturing of DNA is via the application of heat. This is seen particularly with the polymerase chain reaction technique.