∞ generated and posted on 2023.05.31 ∞
Phage titer necessary to decrease numbers of target bacteria during phage therapy.
| Clearance Threshold is those phage numbers that exceed that phage titer which is necessary to exactly balance rates of 'births' of bacteria due to binary fission and rates of deaths of bacteria due to phage adsorption. |
Whether consisting of active treatment or passive treatment, phage titers must come to exceed their clearance threshold in situ for phage therapy to be successful at directly killing bacteria.
Clearance threshold is equivalent to a phage 'minimum bactericidal concentration' (or minimal bactericidal concentration) as well as phage 'inudation threshold' because these are all phage titers that are sufficient to result in net declines in bacterial numbers, with phages effecting those declines by killing targeted bacteria.
Contrast, however, with phage inundative density and see also killing titer. Contrast also ever so slightly with minimum inundatory dose.
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